Semaglutide dosage calculator

5 mg + 2 mL = 2.5 mg/mL, so 250 mcg is 0.1 mL, or 10 units on a U-100 syringe. Change the vial, the water or the amount and the syringe updates.

Also called: "sema", Semaglutide dosage calculator, Semaglutide reconstitution calculator.

Semaglutide reconstitution calculator

Vial mg, water mL and amount give syringe units

mg

Total printed on the vial label.

mL

Diluent volume you add (1 mL = 100 units on a U-100 syringe).

Amount unit

The mass you want in one draw. 1 mg = 1,000 mcg.

Syringe barrel
Show U-40 and U-50 syringes

Result

10units

to draw on a U-100 syringe, 100-unit barrel

Vial: 5 mg with 2 mL diluent 5 mg +2 mL
Syringe filled to 10.0 of 100 units 0 10 20 30 40 50 60 70 80 90 100 U-100, 1 mL
Volume
0.1 mL
Concentration
2.5 mg/mL
Per unit
25 mcg
Draws per vial
20

5 mg + 2 mL = 2.5 mg/mL, so 250 mcg is 0.1 mL, or 10 units on a U-100 syringe.

Arithmetic only. Not a dosing recommendation. Check every figure against your vial label and lab protocol.

How many units is each Semaglutide amount?

At 5 mg + 2 mL (2.5 mg/mL) on a U-100 syringe:

Generated from the calculator's own functions. Rows are evenly spaced reference amounts, not suggested amounts. Amber readings don't fit a 100-unit barrel.

Semaglutide: 5 mg + 2 mL = 2.5 mg/mL, U-100 syringe
AmountmcgVolume (mL)Syringe units
0.1 mg 100 0.04 4
0.25 mg 250 0.1 10
0.5 mg 500 0.2 20
0.75 mg 750 0.3 30
1 mg 1,000 0.4 40
1.5 mg 1,500 0.6 60
1.7 mg 1,700 0.68 68
2 mg 2,000 0.8 80
2.4 mg 2,400 0.96 96
3 mg 3,000 1.2 120 (> 100)
4 mg 4,000 1.6 160 (> 100)
5 mg 5,000 2 200 (> 100)
Engraving of glass burettes, one with a dark strip behind its graduation to make the tick marks easier to read
A burette with a dark strip behind its graduation, 1895. Pick a water volume that lands your reading on a printed mark. Public domain.

How much water for each Semaglutide vial size?

Semaglutide is sold in 4 common sizes (2 mg, 5 mg, 10 mg, 20 mg). The same water volume gives a different concentration in each, so the same reading means a different amount. Each cell shows mcg per unit with mg/mL in brackets.

Semaglutide: mcg per U-100 unit (mg/mL in brackets) by vial size and water added
Vial1 mL2 mL2.5 mL3 mL
2 mg 20 (2)10 (1)8 (0.8)6.67 (0.667)
5 mg 50 (5)25 (2.5)20 (2)16.67 (1.67)
10 mg 100 (10)50 (5)40 (4)33.33 (3.33)
20 mg 200 (20)100 (10)80 (8)66.67 (6.67)

How much bacteriostatic water for a 2 mg Semaglutide vial?

1 mL → 2 mg/mL, so 0.25 mg is 12.5 units. 2 mL → 1 mg/mL, so 0.25 mg is 25 units. 2.5 mL → 0.8 mg/mL, so 0.25 mg is 31.3 units. The whole vial holds 8 draws of 0.25 mg. Full 2 mg Semaglutide page →

How much bacteriostatic water for a 5 mg Semaglutide vial?

1 mL → 5 mg/mL, so 0.25 mg is 5 units. 2 mL → 2.5 mg/mL, so 0.25 mg is 10 units. 2.5 mL → 2 mg/mL, so 0.25 mg is 12.5 units. The whole vial holds 20 draws of 0.25 mg. Full 5 mg Semaglutide page →

How much bacteriostatic water for a 10 mg Semaglutide vial?

1 mL → 10 mg/mL, so 0.25 mg is 2.5 units. 2 mL → 5 mg/mL, so 0.25 mg is 5 units. 2.5 mL → 4 mg/mL, so 0.25 mg is 6.3 units. The whole vial holds 40 draws of 0.25 mg. Full 10 mg Semaglutide page →

How much bacteriostatic water for a 20 mg Semaglutide vial?

1 mL → 20 mg/mL, so 0.25 mg is 1.3 units. 2 mL → 10 mg/mL, so 0.25 mg is 2.5 units. 2.5 mL → 8 mg/mL, so 0.25 mg is 3.1 units. The whole vial holds 80 draws of 0.25 mg. Full 20 mg Semaglutide page →

Worked example: 5 mg vial, 2 mL, 0.25 mg

  1. Concentration. 5 mg ÷ 2 mL = 2.5 mg/mL (2,500 mcg/mL).
  2. Volume. 0.25 mg ÷ 2.5 mg/mL = 0.1 mL.
  3. Units. 0.1 mL × 100 = 10 units on a U-100 syringe.
  4. Check. One unit holds 25 mcg; 10 × 25 mcg = 250 mcg = 0.25 mg, which matches. The vial holds 20 draws of this size.

Semaglutide: notes for the arithmetic

Semaglutide amounts are small (fractions of a milligram), so the reading on the syringe is small too and easy to misread by a factor of ten. FDA reports describe people drawing 50 units instead of 5 units from multi-dose vials. Check that the mL figure and the units figure agree before relying on either.

For the lab procedure itself (materials, aseptic technique, mixing without foaming) see how to reconstitute Semaglutide. For what bacteriostatic water is and how long an opened vial is kept, see the bacteriostatic water guide and the storage guide.

Exact-value lookup: how many units is 0.25 mg of Semaglutide.

Frequently asked questions

How many units is 0.25 mg of Semaglutide?

It depends on the water volume. 5 mg + 2 mL = 2.5 mg/mL, so 250 mcg is 0.1 mL, or 10 units on a U-100 syringe. With 1 mL instead it would be 5 units.

How much bacteriostatic water for a 2 mg Semaglutide vial?

There is no single correct volume. 1 mL gives 2 mg/mL (20 mcg per unit); 2 mL gives 1 mg/mL (10 mcg per unit); 2.5 mL gives 0.8 mg/mL (8 mcg per unit). Pick the volume that makes your reading easy to measure on the barrel you have.

How much bacteriostatic water for a 5 mg Semaglutide vial?

There is no single correct volume. 1 mL gives 5 mg/mL (50 mcg per unit); 2 mL gives 2.5 mg/mL (25 mcg per unit); 2.5 mL gives 2 mg/mL (20 mcg per unit). Pick the volume that makes your reading easy to measure on the barrel you have.

How much bacteriostatic water for a 10 mg Semaglutide vial?

There is no single correct volume. 1 mL gives 10 mg/mL (100 mcg per unit); 2 mL gives 5 mg/mL (50 mcg per unit); 2.5 mL gives 4 mg/mL (40 mcg per unit). Pick the volume that makes your reading easy to measure on the barrel you have.

How many mg of Semaglutide is 10 units?

10 units on a U-100 syringe is 0.1 mL. At 2.5 mg/mL (5 mg in 2 mL) that is 0.25 mg (250 mcg). At a different concentration the answer is different.

Is this a Semaglutide dosing calculator?

It is an arithmetic tool. It converts an amount you enter into a volume and a syringe reading; it does not suggest amounts, schedules or uses. FDA-approved prescription products contain semaglutide (Ozempic, Wegovy, Rybelsus). Research-labeled vials are not those products and are not FDA-approved.

Sources

  1. Wegovy (semaglutide) injection: full prescribing information (revised 06/2026) — Novo Nordisk (FDA-approved label), 2026
  2. FDA alerts health care providers, compounders and patients of dosing errors associated with compounded injectable semaglutide products — U.S. Food and Drug Administration, 2024
  3. FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss — U.S. Food and Drug Administration
  4. Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) — N Engl J Med, 2021, PMID 33567185

Links checked 2026-10-19.